Careers

Position Summary:

This role is a unique opportunity in an energetic company that is based on exciting foundational scientific principles with the prospect of transforming the biological therapeutics landscape and thus, beneficially impacting the lives of millions of patients. The company’s management and founders collectively have decades of R&D, business, and leadership experience at organizations such as Amgen, Chiron, Onyx, ALZA, Five Pri­­me, Second Genome, NGM and Genentech.

The successful candidate will join the downstream processes (DSP) purification group. In this role, protocols for protein purification and in-process analysis characterization of intermediate purified proteins will be developed for heterologous fusion proteins from bacterial source. The development of purification processes will include protein solubilization, refolding, UFDF and protein separation by column chromatography using AKTA systems. A variety of protein separation techniques by column chromatography will be used with purification principals ranging from Ion exchange chromatography (IEC), hydrophobic interactions chromatography (HIC), size-based purification such as size exclusion/gel filtration, and affinity purification strategies.

Key Responsibilities:

• Develop protein purification protocols using AKTA FPLC systems working with a variety of resins in scales ranging from 5 mL to 5 L columns, and a variety of buffers.
• Develop Ultrafiltration/Diafiltration (UFDF) application suitable for scale-up and scale-down purifications.
• Optimize depth filtration processes to enable feed stock clarification.
• Perform in-process analytics utilizing techniques such SDS-PAGE, SEC-HPLC, Reverse phase chromatography, protein solutions spectroscopic and colorimetric measurements, as well as quantitative SEC-HPLC to determine protein concentration of various samples.

Preferred Education/Experience:

• BA/BS or Master’s degree individual with 2-4 years of hands-on work  protein purification experience in a biotech or pharma setting.
• PhD degree individual with or without industry experience.

Knowledge, Skills and Abilities:

• Proficient in downstream purification using Unicorn system on AKTA systems.
• Experience with preparative column packing ranging from 5 – 300 mL.
• Familiarity with protein analytical techniques to perform assays such as HPLC, SDS-PAGE and endotoxin.
• Experience in TFF (ultra-filtration, diafiltration) depth filtration and chromatography.
• Experience in protein concentration methods such spectroscopy (280 nM), colorimetric methods such as Bradford assay, and chromatography methods such as quantitative SEC-HPLC.
• Some experience in protein refolding from E. coli inclusion body is a plus but not necessary.
• Ability to work with multidisciplinary teams.
• Expertise in data analysis software: MS PowerPoint, MS Excel, MS Word and JMP.

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Position Summary:

We are currently seeking a Research Associate to join our team. This individual will be motivated and thrives as part of cross-functional team within Applied Molecular Transport. This an exciting opportunity for an individual motivated to see his work directly impact the development of our lead molecule. The successful candidate will be a bench research associate and key member of the biological sciences. The candidate will help to advance programs from discovery to IND/CTA filing.

Key Responsibilities:

• Develop and perform in vivo, ex vivo, and in vitro studies.
• Assist in developing and performing PK/PD assays for multiple animal models.
• Generate reports and presentations for cross-functional team meetings.
• Actively participate in team meetings to discuss and review data.

Preferred Education/Experience:

• A Bachelor’s/Master’s degree or equivalent experience in pharmacology, physiology, biology, or relevant degree with at least 2 years of hands-on work experience in a biotech or pharma setting.
• Proficiency in designing and executing a variety of in vivo, ex vivo and in vitro studies.

Knowledge, Skills and Abilities:

• Passion to maintain current scientific knowledge focused on pharmacology, toxicology and molecular pharmacology.
• Comfortable at working independently and managing multiple projects in a fast-paced environment.
• Familiarity with animal model development across inflammatory and metabolic diseases.
• Proficiency in designing and executing in vivo PK/PD studies.
• Proficiency with various in vivo skills including dosing (IV, SC, IP, PO), bleeding and harvesting/processing of tissue is a must.
• Experience with ELISA, Western blotting, RT-qPCR, flow cytometry, microscopy and histology is required; experience with Meso Scale Discovery system is a plus.
• Working knowledge of PK/PD principles and software (e.g., WinNonlin, NONMEM, SimBiology, etc)
• Expertise in data analysis software: MS PowerPoint, MS Excel, MS Word and GraphPad Prism.
• The ability to be innovative and creatively solve problems.
• Outstanding written, verbal, and presentation skills are a must.

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Position Summary:

We are currently seeking a Senior Scientist to join our team. This individual will be motivated and thrives as part of cross-functional team within Applied Molecular Transport. This an exciting opportunity for an individual motivated to see his work directly impact the development of our lead molecule. The successful candidate will be a Senior Scientist and key member of the biological sciences. The candidate will help to advance programs from discovery to IND/CTA filing.

Key Responsibilities:

• Develop and lead the analysis of preclinical (PK, ADA, biomarker) samples in support of various stage of preclinical and clinical studies.  
• Perform primary (QC) data review for the assays and results
• Trouble shoot assay performance.
• Generate reports and presentations for cross-functional team meetings.
• Actively participate in team meetings to discuss and review data.

Preferred Education/Experience:

• A Bachelor’s/Master’s degree or equivalent experience in biology, or relevant degree with at least 10 years of hands-on work experience in Bio Analytical in a biotech or pharma setting.
• Experience on IND and EMA filing.
• Proficiency in designing and executing a variety of Bio Analytical Methods (PK/PD and ADA assays, analytical immunoassays including antibody binding assays, ELISA, MSD, Luminex, biosensor, flow cytometry, SDS-PAGE or HPLC).

Knowledge, Skills and Abilities:

• Passion to maintain current scientific knowledge focused on Bio Analytical Methods.
• Comfortable at working independently and managing multiple projects in a fast-paced environment.
• Experience and knowledge in polyclonal and monoclonal antibody generation using hybridoma, phage display, and/or B-cell approaches.
• A strong background in immunology, antibody characterization and immunoassay development.
• Manage sample logistics and Partner with CROs to manage and monitor outsourced PK/ADA assays.
• Extensive track record of successfully developing bioanalytical methods for biopharmaceuticals.
• The ability to be innovative and creatively solve problems.

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Position Summary:

Applied Molecular Transport is seeking an experienced Document Control Specialist for our South San Francisco, CA office. The candidate will perform duties to plan, organize, and execute the corporate document control function, such as processing change requests, managing the document control system and archiving records for storage and retrieval.

Key Responsibilities:

• Create, edit and make effective controlled documentation related to process changes or document revisions.
• Route Change Requests/document revisions to internal customers and key stakeholders for approval.
• Update, manage, and maintain company procedures and production records in close cooperation with functional area representatives.
• Maintain Master Documents and document trackers for GXP activities.
• Administer SOP training when applicable; train AMT employees and/or contractors on entering and accessing data within the Document Management System.
• Prepare documents for offsite storage, arrange for offsite destruction of eligible documents and conduct audits of offsite archived storage.
• Ability to prioritize multiple competing assignments
• Assist in the establishment of an electronic document storage system.
• Support document control related projects as necessary for other internal groups such as CMC, Facilities and Regulatory Affairs management, etc.
• Assist in the preparation & distribution of document control metrics and reports.
• Provide general support for the overall Quality System.

Preferred Education/Experience:

• 4+ years in document control or records management in a biotech/pharma cGXP environment
• A bachelor’s degree is required 

Knowledge, Skills and Abilities:

• Proficient with a computer (MS Office) with internet skills
• Experience from working with many file types
• Be highly organized with attention to detail in a fast-paced environment
• Ability to manage multiple tasks with excellent record-keeping and organizational skills
• Excellent written and verbal communication skills
• Excellent collaborative skills
• Self-Starter with a positive attitude

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Position Summary:

The Clinical Trial Manager/Senior Clinical Trials Manager will be responsible for the operational management and oversight of clinical trials within a clinical development program. The position will work closely with the Medical Monitor and other cross-functional representatives including Clinical Data Management, Biostatistics, Regulatory/QA, Pharmacology and Biology to ensure successful completion of all clinical activities/project deliverables within the required time frame and budget. The position will also provide oversight of the CRO and other third-party vendors on the assigned study. This individual will report into the Head of Clinical Operations.

Key Responsibilities:

• Responsible for the planning, implementation and conduct of large, global, complex clinical trials in Phase I-IV; or multiple smaller early-phase studies. 
• Responsible for oversight and project management of individual studies as well as relevant program related activities with minimal supervision. 
• Provides leadership within the department and makes recommendations with regards to the operational aspects of executing clinical development deliverables.   
• Actively provides operational direction and/or general supervision to direct reports
• Assist with training and mentoring of internal clinical operations staff. 
• Establish study milestones and ensure accurate tracking and reporting of study metrics and timelines. 
• Manage CROs, vendors and consultants that are involved with the clinical trial and program. 
• Track and report on progress of study including site activation, patient enrollment, monitoring visits
• Perform clinical data review of data listings and summary tables, including query generation  
• Identify, select, and monitor performance of investigational sites for clinical studies; prepare accurate and timely visit reports from all site interaction visits
• Develop and maintain good working relationships with investigators and study staff
• Ensure studies are carried out according to the study protocol, SOPs, and ICH/GCP regulations and study-specific manuals and procedures
• Review key study quality metrics (e.g., eligibility, primary endpoint data, etc.) and determine appropriate action in conjunction with study team (autonomy may vary with experience)
• Investigate queries, monitor discrepancies
• Manage investigational product (IP) accountability and reconciliation process
• Responsible for review or approval of IP release packages
• Negotiate and manage the budget and payments for investigative sites
• Develop CRA and third-party vendor training on protocols and practices 
• Participate in program strategy meetings, ad hoc clinical operations’ initiatives and programs as assigned. 
• Write or contribute to the preparation of clinical protocols, amendments, informed consent forms, study guides, case report forms, and any other clinical research related documents
• Perform initial review of CRO and other third-party study vendor invoices to ensure that work is performed in accordance with scope of work

Preferred Education/Experience:

• Bachelor’s degree or higher in a scientific or healthcare discipline preferred with minimum of 5-7 years of progressive experience in clinical research and clinical operations preferably within the biotech, pharmaceutical sector, or CRO environment. Prior experience managing people is desired.

Knowledge, Skills and Abilities:

• Extensive experience managing clinical programs, CROs, budgets, and timelines required
• Proven experience in the oversight of the operational aspects of all stages of clinical studies
• Ability to organize and manage multiple priorities required
• Ability to thrive in a fast-paced, entrepreneurial environment with busy, high performing colleagues
• Ability to function at a high level in a team setting whether leading the group or acting as an individual contributor
• Proactive and positive management approach
• Maximum flexibility to adapt to changing program needs in real time
• Strong leadership skills and self-awareness
• Ability to build strong relationships with co-workers of various backgrounds and expertise

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Applied Molecular Transport are looking for an experienced Fermentation Scientist/Engineer to develop, optimize and scale-up upstream processes for the production of biopharmaceutical proteins.

Primary Responsibilities

• Development and execution of upstream processes to produce novel therapeutic proteins at lab scale.
• Set-up and operation of fermentation equipment ranging from 200mL to 30L.
• Process monitoring and sampling, including performing routine sample analysis using biological, biochemical, and analytical chemistry assay techniques.
• Preparation of media, solutions and buffers.
• Participation in daily operation and routine maintenance of process and analytical equipment.  Maintaining a clean and organized lab environment. Chemicals and consumables stocking, etc.
• Maintenance of lab notebooks and batch records, preparation of SOPs and other technical documentation.

Required Skills

• Operation of lab scale fermentation/cell culture equipment, including: fermentors, pH meter, autoclaves, laboratory scales and centrifuges.
• Competence in analysis and presentation of experimental results.
• Excellent interpersonal and communication (oral and written) skills, documentation, organization, good record keeping, writing reports and SOPs.
• Proficiency in cell culture and aseptic technique
• Strong technical competency in the scientific principles of fermentation, microbiology and basic chemistry
• Attention to detail, safety and good laboratory practice.

Required Experience

• A Bachelor’s/Master’sPhD degree or equivalent experience in Chemical Engineering or Microbiology or related field.
• At least 2 years of hands-on lab experience working with fermentation equipment.

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Applied Molecular Transport is developing targeted oral biological therapeutics to treat autoimmune, inflammation and other diseases, including those associated with cancer, metabolic and hepatologic disorders.  Our pipeline is based on deep scientific foundations in mucosal immunology and microbiome-epithelial interfaces.  Our overriding patient-centric goal is to advance novel biological opportunities to enhance therapeutic outcomes and improve drug safety profiles.

We are seeking a talented scientific professional to join our team developing novel dosage forms to advance the therapeutic potential of our pipeline.

Research Associate, Pharmaceutical Sciences

• The candidate will have knowledge and hands-on experience in drug development and characterization, ideally including protein formulation development, oral dosage form development, and associated analytical techniques (HPLC, SEC, etc).
• The candidate will design and conduct laboratory experiments and will be a key member of the research department based in our state-of-the-art labs.
• The candidate will help advance programs from early discovery to the clinic.

Primary Responsibilities

• Laboratory science in support of formulation development.
• Conceive, design, execute, analyze and interpret experiments.
• Present results to supervisor, internal groups and senior management.

Required Experience and Qualifications

• BS/MS in Chemistry, Biochemistry, or Analytical Chemistry.
• 1-4 years of pharmaceutical or biotech experience in a relevant area, such as formulation development, analytical methods, biologic drug molecules.
• Evidence of independent scientific aptitude.

Who You Are

• Demonstrated ability for timely delivery of high-quality results.
• Familiar with analytical software such as Agilent chem-station or Thermo Fisher  and data analysis.
• Strong written, verbal, and presentation skills.

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Applied Molecular Transport, Inc. is looking to hire a quality control analyst to support its cGMP manufacturing campaigns. The successful candidate will have extensive understanding of protein analytical methods and raw material testing. The position will involve regular communication and collaboration with upstream & downstream manufacturing and quality assurance functions.

Primary Responsibilities:

• Perform chemical analyses of incoming raw materials and in-process samples under cGMP to support biologics manufacturing.
• Maintain log of raw materials and laboratory reagent and reference standard inventories.
• Maintain cGMP QC laboratory following compliance procedures.
• Coordinate outsourced laboratory testing activities.
• Evaluate QC results and trend data.
• Participate in OOS, OOT investigations and prepare reports.
• Off-shift emergency testing in support of manufacturing.

Qualifications:

• Practical experience with HPLC, electrophoresis, UV-Vis, FT-IR and other analytical methods.
• Experience in GLP or GMP QC environment.
• Experience with compendial testing (USP, EP, JP).
• Experience with Microsoft Office and LIMS.
• Strong written and verbal communication skills.
• Time management skills and ability to meet deadlines.

Education:

• BS or equivalent degree in chemistry, biochemistry, biological sciences, pharmaceutical sciences or a related discipline.
• 5 years of experience in the biotech/pharmaceutical industry.

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Position Summary:

The Senior Administrative Assistant is responsible for general office support with an emphasis on office management/purchasing and accounting support. In addition to general office support tasks, the Administrative Assistant will also support the management team with various ad-hoc projects.

Key Responsibilities:

 Office/Laboratory:

• Keep office clean and organized.
• Greeting and directing guests in a professional, friendly, hospitable manner.
• Answering incoming calls and direct calls to appropriate personnel.
• Scheduling candidate interviews.
• Ordering office supplies as needed, including recycling printer cartridges.
• Ordering or picking up food and kitchen supplies.
• Coordinating all company events.
• Onboarding of new hires, including computer/lab set up.
• Coordinating facility repairs & maintenance

Accounts Payable:

• Processing payment of expense reports.
• Review all invoices for appropriate documentation and approval prior to payment.
• Enter invoices in accounting system for payment.
• Process weekly check run.
• Initiate ACH payments in online banking platform.
• Reconcile vendor statements, research and correct discrepancies.
• Respond to all vendors inquires.
• Maintain vendor files and documentation thoroughly and accurately.
• Support Audit requests for procurement and payment documentation.

Purchasing:

• Serve as primary contact for purchasing.
• Coordinate purchases for all AMT team members, including vendor set up/negotiation and logistics coordination.
• Coordinate issuance of POs as needed.
• Source purchase requests from preferred vendors.

Preferred Education/Experience:

• 5-7 years of relevant experience in an office coordination, administrative, or support role.
• Certificate or Associate Degree.
• Bachelor’s degree preferred.

Knowledge, Skills and Abilities:

• Excellent oral communications skills including a professional, friendly phone manner.
• Excellent written communication skills.
• Proficiency with Microsoft office applications.
• Experience with QuickBooks Online.
• Attention to details and problem-solving skills.
• Excellent time management skills and ability to multi-task and prioritize work

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Position Summary:

We are currently seeking a hands-on scientist to join our team. This individual will be a motivated scientist that thrives as part of cross-functional team within Applied Molecular Transport and with external academic/industry collaborators. This an exciting opportunity for an individual motivated to see his work directly impact the development of our lead molecules as they progress through clinical trials.

Key Responsibilities:

• Provides scientific expertise in areas of biomarker discovery, development, and translational science working with multiple cross-functional teams (e.g. biology, preclinical and clinical).
• Generates in vivo, ex vivo and in vitro models of disease to identify and implement new biomarkers of clinical relevance (pharmacodynamic, predictive of patient-response, prognostic and safety) by leveraging both internal capabilities and external collaborators and contract research organizations.
• Prepares and communicates scientific reports (written and verbal) to project teams.
• Work with clinical team in the coordination of biological specimen sample collection, handling, analysis, and storage for biomarker analysis.
• Perform hypothesis driven experiments to support clinical differentiation opportunities for AMT’s pipeline.
• Participating in discussions to formulate disease area strategy for target selection and validation.

Preferred Education/Experience:

• PhD with 5 or more years of experience in immunology post-degree.
• At least 3 years of pharmaceutical or biotechnology industry experience with expertise in biomarker and translational models.

Knowledge, Skills and Abilities:

• Extensive experience in human primary cell culture including iPSC-based in vitro models of disease. Experience with High-content Imaging systems is a plus.
• Proficiency in tissue culture and primary immune cell assays.
• Experience working with mouse models of disease.
• Proficient in flow cytometry, including preparation of samples, analysis and sorting
• A strong track record of intellectually challenging oneself to enhance scientific capabilities
• Scientifically rigorous, highly organized, and with significant attention to detail
• Ability to work independently as well as collaborate with peers and effectively work in a results oriented research team environment

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Position Summary:

Applied Molecular Transport, Inc. is looking to hire a research associate in analytical method development and quality control (AD & QC) for its therapeutic programs. The successful candidate will have extensive understanding of protein chemistry, protein characterization, and analytical techniques. The position will involve regular communication and collaboration with an interdisciplinary team within AMT and with outside contractors/consultants.

Key Responsibilities:

• Perform analytical method development for LC based assays such as SEC, IEX and reversed-phase HPLC, and other protein-based analysis (i.e. SDS-PAGE, western blot, A280)
• Provide testing support for the in-house manufacture of drug substance and drug product
• Execute stability studies to evaluate and characterize protein degradation during storage
• Process data and present findings at regular team meetings
• Write technical reports
• Document operating procedures for technology transfer and work with CROs/CMOs to implement methods in a GMP environment

Preferred Education/Experience:

• BS, MS, PhD or equivalent degree in chemistry, biochemistry, biological sciences, pharmaceutical sciences or a related discipline
• 1-5 years of experience in the biotech/pharmaceutical industry

Knowledge, Skills and Abilities:

• Practical experience with protein chemistry, degradation and stabilization mechanisms
• Experience with HPLC, electrophoresis, UV-vis spectroscopy and other analytical methods
• Interpersonal skills and ability to contribute to the success of a team
• Strong written and verbal communication skills
• Time management skills and ability to meet deadlines
• Additional analytical techniques: cIEF, mass spec, ELISA, bioassay, peptide mapping
• Experience with solid dosage form analysis (i.e. dissolution, particle sizing)
• Experience in GLP or GMP environment
• Management of external CROs/CMOs a plus

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)