Careers

Applied Molecular Transport (AMT) is a biopharmaceutical company with transformative platform technologies that drive the creation of next generation biological therapeutics, with a particular focus on oral, site-specific targeting to the GI tract, hepatic portal biology, as well as to systemic circulation.

We are a rapidly growing and fast paced company applying foundational scientific principles with the prospect of transforming the biological therapeutics landscape and beneficially impacting the lives of millions of patients who have little to no options.

AMT is looking for top-tier candidates that have a passion and commitment to support the development of the medicines, therapies and 21st century cures that improve and save people’s lives and impact the future of healthcare.

Our team brings industry R&D, business and leadership experience drawn from organizations including Genentech, Amgen, Gilead, AbbVie, Merck, NGM Bio, Sutro Biopharma, BioMarin, Bayer, Lonza, Affymax, Onyx, Kythera, and Celgene.

Note to External Recruiters:
All candidate activity and open positions are managed strictly through our internal recruitment team. Our Human Resources Department kindly requests that recruiters not contact employees/hiring managers directly to solicit business and present candidates. Submission of unsolicited resumes prior to an agreement set in place between AMT and the recruiting agency will not create any implied obligation. Inquiries on developing a recruiting relationship with us, may be directed to: recruiting@appliedmt.com

Available Positions

QA Specialist »

Applied Molecular Transport (AMT) is developing targeted oral biological therapeutics, with the patient-centric goal of expanding biological possibilities to enhance therapeutic outcomes and improve drug safety profiles. Our technology platform is fueling a unique pipeline of first-in-class molecules to treat a wide range of diseases, including autoimmune, inflammation, cancer, metabolic and hepatologic disorders. Our products mimic the biology of microbial and other natural processes that modulate health and disease via mucosal immunology.

AMT is seeking a highly motived individual with quality review and disposition of raw materials and product batch record experience. As the QA Specialist, you will interface with a diverse internal team across Materials Management, Manufacturing and Quality Control functions. This role requires the ability to effectively communicate with cross-functional teams, independently manage timelines, and continually strengthen external department relations. You will need to be organized and detail oriented with strong and effective written, verbal, mathematical, and interpersonal communication skills. This role will require you to have the ability to work independently within prescribed guidelines and collaboratively as part of a team as well as be able to obtain direction and commitment to ensure that projects are completed by deadlines and streamlining processes to maximize productivity. This role will also require the ability to work successfully, strategically, and tactically in a fast-paced, multi-disciplinary environment with potential for rapidly changing priorities. This position has the utmost responsibility for compliance with the rules and regulations regarding a safe and healthy work environment relative to their actions. Off-shift, weekend and overtime duties may be required as assigned by the manager of the employee.

Primary Responsibilities include, but are not limited to:

Performing product inspections and facility inspections
Line Clearances
General product observations
Reviewing Master Batch Records, Executed Batch Records, Deviations, Out-of-Specification documentation
Logging, monitoring and trending quality related data
Quality on the floor, as per the manufacturing schedule
Ensure all necessary documentation is prepared and coordinated between various departments (MFG/QC/MM)

Required Experience and Qualifications

BS degree in a scientific discipline
Strong attention to detail
3+ years of direct experience within Quality in a GLP/GCP/cGMP environment
2+ years of direct experience creating, revising, reviewing, and approving of controlled documentation
Direct experience with MasterControl for document management, deviations, change control, CAPA and standalone forms
Knowledge of governmental regulatory guidelines, directives and regulations relating to the manufacturing of biologics
Cleanroom experience
Experience working effectively with cross-functional teams in a fast-paced, dynamic environment
Strong understanding of cold chain management
Excellent interpersonal, verbal, and written communication skills are essential in this collaborative work environment
Comfortable in a fast-paced small company environment with minimal direction and able to adjust workload based on changing priorities
Excellent organizational skills and an ability to prioritize effectively to deliver results within established timelines
Internal/external audit experience is preferred but not mandatory
GMP raw materials/consumable Quality support for inventory management/investigation is preferred but not mandatory

Reports to: Sr. Manager Quality

Location: South San Francisco, California

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

AMT is an equal opportunity employer. In accordance with applicable law, AMT does not discriminate in hiring or otherwise in employment based on race, color, religion, sex, national origin, age, marital or veteran status, disability, sexual orientation, or any other legally protected status. EOE/AA/Vets

Associate Director/Principal Scientist, Pharmaceutical Sciences »

Applied Molecular Transport is developing targeted oral biological therapeutics, with the overriding patient-centric goal of expanding biological possibilities to enhance therapeutic outcomes and improve drug safety profiles.

Our technology platform is fueling a pipeline of first-in-class molecules to treat a wide range of diseases, including autoimmune, inflammation, cancer, metabolic and hepatologic disorders. Our products mimic the biology of microbial and other natural processes that modulate health and disease via mucosal immunology.

We are seeking a talented scientific professional to join the Pharmaceutical Science team to develop novel dosage forms to advance our innovative technology platform. This role is responsible for defining and implementing laboratory strategies for oral drug product innovation, formulation development and manufacturing support for our pipeline of biologic products. This position will support development teams to bring proprietary biopharmaceuticals through clinical development.

Primary Responsibilities

Key role in developing formulations for AMT pipeline biologic products
Evaluate novel biologic molecules and determine suitable formulation approach to meet pre-clinical and clinical requirements
Design and conduct experiments to achieve stable, high-performing formulations
Collaborate with analytical team for characterization and method development
Support internal teams and CROs with materials and documentation for required studies
Represent Pharmaceutical Science function on project teams and provide formulation input to overall development plans
Formulation leadership role on external collaborations and internal projects
Identify and select external partners to support formulation needs
Support regulatory filings by contributing to drug product CMC sections.
Support drug product development and tech transfer activities to contract manufacturing sites
Prepare verbal presentations, technical memos and reports
Recruit and supervise Research Associates, Scientists or other lab staff

Education/Experience

PhD in chemistry/biochemistry/analytical/chemical engineering or related field
7+ years industry experience (or MS with 12+ years industry experience) in biopharmaceutical formulation development or related field

Knowledge, Skills and Abilities

The ideal candidate will have the following attributes and experience:

Hands on experience and knowledge in biologics formulation development and characterization
Good understanding and practical application of chromatographic and other analytical techniques for protein therapeutics
Expertise in developing phase-appropriate formulations for protein therapeutics, including experience with US/EU regulatory and quality requirements
Experience with CRO selection and relationship management
Excellent written and verbal communication skills
Team-oriented work style, with effective conflict-resolution and stake-holder management skills
Flexible to changing priorities and timelines

Reports to: Vice-President, Pharmaceutical Sciences

Location: South San Francisco, California

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Scientist/Sr. Scientist »

Position Summary:

The Scientist/Sr. Scientist position is within AMT’s analytical development group that is based at Tower Place, South San Francisco. In this role, the scientist will perform method development, qualification, and technology transfer for the release and stability testing of drug substance and drug products. The position will report to Director of Analytical Development and collaborate with cross-functional teams at AMT.

Key Responsibilities:

Perform analytical method development for LC based assays such as SEC, IEX and reversed-phase HPLC, and other protein-based analysis (i.e. SDS-PAGE, CE-SDS, A280, etc.)
Provide testing support for the in-house manufacture of drug substance and drug product.
Execute stability studies to evaluate and characterize protein degradation during storage
Process data and present findings at regular team meetings
Document operating procedures for technology transfer and work to implement methods in a GMP environment
Write technical reports

Preferred Experience/Education:

BS, MS, PhD or equivalent degree in chemistry, biochemistry, biological sciences, pharmaceutical sciences or a related discipline
1-5 years of experience in the biotech/pharmaceutical industry preferably in a regulated environment

Knowledge, Skills and Abilities:

Practical experience with protein chemistry, degradation and stabilization mechanisms
Experience with HPLC, electrophoresis, UV-Vis spectroscopy and other analytical methods
Interpersonal skills and ability to contribute to the success of a team
Strong written and verbal communication skills
Time management skills and ability to meet deadlines
Experience with solid dosage form analysis (i.e. dissolution, assay, KF, etc.)

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Manager, Clinical Supply »

Position Summary:

AMT is seeking a highly motived individual with planning, scheduling, logistics and distribution (inbound /outbound) experience. As the Manager, Supply Chain, you will interface with a diverse internal team across Clinical, Manufacturing and Quality functions as well as external partners to support the coordination of inbound and outbound logistics activities. The position’s primary responsibility is managing clinical supply, scheduling and monitoring the on time and in-full delivery of product to depots or clinical sites.

Key Responsibilities:

Manage pharmaceutical supply-chain and distribution activities for AMT clinical drug products
Coordinates and monitors all shipment activities initiated by AMT or at the request of contract sites (depots or clinical sites)
Lead interaction and establish effective collaboration with contract partners to meet timelines for packaging, labeling, and on-time distribution to global clinical sites
Collaborate with internal partners to develop short- and long-range plans for product inventory, depot and distribution strategies
Determine import/export requirements and shipping logistics to required countries
Manage global shipment schedule for inbound and outbound shipment requests
Ensure all necessary documentation is prepared and coordinated between depots and sites
Monitor critical shipments across each leg of transport and resolve shipping-related issues with freight forwarders and customs brokers
Maintains courier and lane specific metric control plan
Reports and investigates shipping incidents with Quality
Reviews inventory reports for quantity, lot status and expiration dates
Investigates and resolves inventory discrepancies in a timely manner
Coordinate deliveries between manufacturing sites and 3PL providers, in some cases, manages physical materials movement and receipt into facilities and labs, as needed
Identify risks and sensitivities to drug supply and work with internal partners to develop and implement mitigation strategies
Develop budgets, maintain invoice control and financial tracking

Preferred Experience/Education:

BS/MS degree
5+ years of direct experience in supply chain/distribution management in biopharmaceutical field
Experience working effectively with cross-functional teams in a fast-paced, dynamic environment
Strong understanding of cold chain management

Knowledge, Skills and Abilities:

Knowledge and understanding of international pharmaceuticals shipping requirements
Additional specific qualifications in clinical supplies demand and logistics/or planning management including APICS, CPIM and related professional certifications preferred
Demonstrated knowledge of quality systems, packaging and labeling capabilities, shipping and logistics for pharmaceutical products
Experience with managing contract manufacturing/distribution partners for pharmaceutical supply-chain activities
Excellent interpersonal, verbal and written communication skills are essential in this collaborative work environment
Comfortable in a fast-paced small company environment with minimal direction and able to adjust workload based on changing priorities
Excellent organizational skills and an ability to prioritize effectively to deliver results within established timelines

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Associate Scientist »

Position Summary:

We are seeking a talented and dynamic Associate Scientist to support efforts in the discovery and development of novel, oral biological therapeutics to treat severe autoimmune, metabolic and inflammatory diseases. The successful candidate will be responsible for the design and execution of laboratory experiments aimed at characterizing novel therapeutics and developing biomarker assays to support clinical trials. Expertise in common immunology and molecular biology lab methodologies is required.

Key Responsibilities:

Design and perform laboratory experiments to support biomarker discovery and assay development
Generate, analyze, and summarize data from studies for inflammatory disease programs.
Work independently as needed, as well as collaboratively with colleagues within and across functional areas
Author nonclinical pharmacology reports and present in group / project team meetings

Preferred Experience/Education:

Applicants must have a B.S. / M.S. in a science-related discipline and at least 10 years of relevant experience, preferably in industry and drug development.
Depth of knowledge and experience in immunology and molecular biology with applications towards cellular assay development. Direct experience in the investigation of pathways or interventional targets related to mucosal immunology and inflammatory bowel disease is optimal.

Knowledge, Skills and Abilities:

The successful candidate must have demonstrated proficiency in laboratory techniques in the area of immunology and molecular biology. Experience with most or all of the following is required: Flow cytometry, qPCR, ELISA and/or MSD, western blotting, cell culture, cloning/CRISPR
Demonstrated excellence in designing and executing plate-based cellular assays
Excellent data analysis, critical thinking, and communication skills (both written and verbal) and interpersonal skills are required. Must be able to work independently and have strong organizational and planning skills.
Ability to use Excel, GraphPad Prism and FlowJo to analyze experimental results and generate data figures

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Sr. Manager/Associate Director, Regulatory Affairs (Clinical) »

Position Summary:

This position will support regulatory activities related to assigned company products, including but not limited to collecting and summarizing regulatory intelligence, participation in project teams, providing input for regulatory submissions, and managing the compilation and review of all submissions for completeness and quality. This position will participate in the compilation and production of various regulatory submissions with a focus on nonclinical/clinical aspects according to timelines and in compliance with established submission standards, including eCTD requirements. Responsible to ensure all RA deliverables of moderate complexity associated with each project or other assignment are completed within defined timelines and meet regulatory and other company guidelines.

Key Responsibilities:

In conjunction with Regulatory Affairs department leadership, ensure optimal acceptable regulatory strategies for worldwide compliance and submissions
Provide regulatory guidance to cross-functional teams for assigned projects and manage the preparation of INDs and CTAs in accordance with agreed timeframes
Manage regulatory projects and closely collaborate with Clinical, Nonclinical/Translational, other scientific and technical departments and external vendors to coordinate and implement submission strategy
Works with technical and medical writing to manage document preparation timelines and communicates with team members to maintain awareness of expectations, enable timely reviews, achieve milestones and document deliverables.
Lead preparations for, and participate in, meetings with regulatory agencies
Communicate with regulatory agencies regarding submission strategies, potential regulatory pathways, or clarification and follow-up of submissions under review
Provide review of data or reports that will be incorporated into regulatory submissions to assure scientific rigor, accuracy, and clarity of presentation
Review clinical protocols to ensure collection of data needed for regulatory submissions

Preferred Education/Experience:

Minimum BA/BS degree, and / or equivalent experience in a health science field. Advanced degree desirable.
Minimum 4 years pharmaceutical industry experience, 3 years regulatory experience with increasing responsibility.
Broad understanding of domestic and international regulations, processes and issues in drug/biologics development.
Working knowledge of GMP, GLP, and GCP regulations as well an understanding of the pharmaceutical product life cycle
Experience in the preparation and submission of regulatory documents in support of INDs, global CTAs preferred
Strong computer skills, including Microsoft Office Suite (Word, PowerPoint and Excel) and Adobe Acrobat

Knowledge, Skills and Abilities:

Capable of critically reviewing complex technical documents and influencing colleagues across functions
Must be able to work on multiple projects simultaneously and demonstrate organizational, prioritization, and time management proficiencies
Excellent interpersonal, verbal and written communication skills are essential in this collaborative work environment internally and externally
Willingness to think outside of the box and adapt best practices and ability to adapt in a constantly evolving environment
Self-motivated with a strong sense of ownership in areas of responsibility
High degree of professionalism, ethics and integrity
Comfortable in a fast-paced company environment with minimal direction and able to adjust workload based upon changing priorities
History of successful interactions with global regulatory authorities
Able to perform independently and think analytically and creatively to solve problems
Ability to be a true team player working toward common goals
Willing to travel domestically and internationally up to 15%

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Associate Director, CMC Regulatory »

Position Summary:

The AD, CMC will be a key partner in a cross-functional team setting to manage and execute global CMC regulatory strategies and provide regulatory guidance to multiple project teams to ensure compliance with relevant regulations, guidelines, and industry standards. The successful candidate will participate in the planning, preparation, and review of CMC-related regulatory documentation to ensure its suitability for submission to health Responsibilities. Support the evaluation of proposed manufacturing changes for global impact to ongoing and existing filings, and providing strategic regulatory guidance for optimal implementation of changes. Research and interpret global CMC regulations and provide strategic direction and regulatory guidance to the Quality, Manufacturing, Process Development, and other functional groups within the technical operations organization.

Key Responsibilities:

Represent Regulatory Affairs as the CMC SME for the department and act as a liaison between regulatory affairs and other functional areas at AMT
Develop regulatory strategy and execute regulatory submissions to support CMC activities
Develop and maintain detailed timelines for regulatory activities and submissions while assuring that planning and coordination of activities is executed to plan with the Regulatory Affairs lead actively driving the process.
Prepare, author, review, coordinate and manage CMC regulatory submissions, including original IND/IMPD, IND/IMPD amendments, annual reports, agency meeting briefing documents and CMC sections of the BLA/MAA in accordance with applicable regulations and eCTD format where applicable
Manage all the regulatory submission documents and the associated supporting documents and collaborate closely with AMT CMC and external vendors and collaborators
Closely interact with AMT process and analytical development groups, QA, QC and regulatory to deliver successful clinical trials and marketing authorizations by providing strategy guidance to the Company on CMC regulatory requirements
Represent Regulatory Affairs in cross-functional team meetings and translate current regulatory requirements and proposed CMC changes into practical, workable submission plans and strategies
Research and disseminate regulatory intelligence on trends in regulatory affairs in CMC biologics and solid dosage forms, and industry standards for CMC Regulatory work.

Preferred Education/Experience:

BA/BS degree in life sciences in chemistry, molecular biology, immunology or similar. PhD or other advanced degree desirable. Demonstrable experience in Regulatory Affairs with a minimum of 5 years in CMC regulatory.

Knowledge, Skills and Abilities:

Strong technical writing and editing skills.
Comprehensive understanding of FDA, EMA and ICH requirements, including for the development of biologics
Demonstrated ability to coordinate and work effectively with cross-functional teams across multiple projects with varying priorities while adhering to established timelines
Experience with delivery of regulatory submissions in eCTD format

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Accounts Payable Specialist »

Position Summary:

We are seeking an Accounts Payable Specialist to join our team. This position will report directly to the Director of Accounting Operations and will be responsible for the full accounts payable function including invoice process and vendor payments. They will be responsible in managing vendor relationships as well as keep close communications with departments across the organization.

Essential Functions:

Entering bills into NetSuite in an accurate and timely manner
Perform full cycle accounts payable processing: invoice data capture, coding with correct account and department information, and posting payments
Review and reconcile invoice discrepancies
Manage accounts payable inbox, and respond to vendor inquiries
Perform weekly payment cycle (checks and electronic funds transfers)
Responsible for preparation and filing of 1099s to ensure compliance with IRS guidelines
Manage vendor relations and reconciliation.
Assist with audits as needed
Perform other accounting and administrative duties as assigned

Preferred Experience:

2 to 5 years accounts payable experience.

Preferred Education:

Associate degree preferred

Additional Skills (i.e., Computer):

NetSuite or other ERP experience.
Proficiency in MS Office applications, primarily Excel, Word and Outlook.
Ability to solve problems, multi-task, and work in fast paced environment.
Ability to prioritize workload and meet critical deadlines.
Strong organizational skills.
Self-starter and ability to work autonomously.
Excellent verbal and written communication skills.

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Research Associate; Upstream Process Development »

Position Summary:

Applied Molecular Transport are looking for an experienced Fermentation Research Associate to develop, optimize and scale-up upstream processes for the production of biopharmaceutical proteins.

Primary Responsibilities

Development and execution of upstream processes to produce novel therapeutic proteins at lab scale.
Set-up and operation of fermentation equipment ranging from 200mL to 30L.
Process monitoring and sampling, including performing routine sample analysis using biological, biochemical, and analytical chemistry assay techniques.
Preparation of media, solutions and buffers.
Participation in daily operation and routine maintenance of process and analytical equipment. Maintaining a clean and organized lab environment. Chemicals and consumables stocking, etc.
Maintenance of lab notebooks and batch records, preparation of SOPs and other technical documentation.

Required Skills

Operation of lab scale fermentation/cell culture equipment, including: fermentors, shake flasks; pH meter, autoclaves, laboratory scales and centrifuges.
Competence in analysis and presentation of experimental results.
Excellent interpersonal and communication (oral and written) skills, documentation, organization, good record keeping, writing reports and SOPs.
Proficiency in cell culture and aseptic technique
Strong technical competency in the scientific principles of fermentation, microbiology and basic chemistry
Attention to detail, safety and good laboratory practice.

Required Experience

A Bachelor’s/Master’sPhD degree or equivalent experience in Chemical Engineering or Microbiology or related field.
At least 2 years of hands-on lab experience working with fermentation equipment.

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Senior Scientist, Protein Science »

Position Summary:

We are seeking a skilled and experienced researcher to join a team focused on the expression and characterization of novel biologic drug candidates that modulate inflammation for the treatment of human diseases.

The successful candidate will be responsible for expressing, purifying, and characterizing recombinant proteins in support of discovery and preclinical development programs. Demonstrable experience with protein expression and purification techniques and protein analytical/characterization methods is required. Strong data analysis skills, the ability to prepare written reports, the ability to present results at research team meetings, and the ability to work productively and collaboratively within a tight-knit team are key assets for this position.

Key Responsibilities:

Strong scientific grounding in protein chemistry and protein structure and function.
Production of recombinant proteins from e. coli cells at up to 1 liter scale.
Experience with refolding of proteins highly desirable.
Laboratory experience in protein purification (e.g. affinity chromatography, size exclusion chromatography, ion exchange chromatography).
Laboratory experience in protein analytical techniques (e.g., SDS-PAGE, HPLC, Western Blot).
Perform data analysis and summarize experimental results, with supervision as appropriate.
Prepare and maintain buffers, reagents and media.
Ensure sufficient laboratory supplies for daily laboratory operations.
Organize, record and maintain experimental data.
Ensure proper operation and perform routine maintenance of laboratory equipment.
Assist other staff to complete laboratory tasks as necessary.
Maintain a clean and safe work environment

Preferred Education/Experience:

B.S. in Biochemical, Chemical, and Biology related discipline with 4-6 years of relevant experience or an MS with 2-4 years, or PhD with 0-2 years. Title and salary will be commensurate with the candidate’s qualifications.

Knowledge, Skills and Abilities:

Must have excellent organization skills and ability to handle multiple tasks.
Highly motivated, willingness to acquire new skills and ability to work with minimal supervision.
Excellent verbal and written communication skills.
Must be proficient in Microsoft Word, Excel, etc.

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Bioassay Analyst, QC »

Position Summary:

Bioassay Development/QC is looking for an analyst with experience in cell-based assay, ELISA or Enzyme/potency/binding plate-based assays. The successful candidate will primarily be responsible to perform laboratory-based activities to design, develop and qualify analytical methods for the characterization, as well as release testing of the Company’s therapeutic drug substance and drug products.

Key Responsibilities:

Develop and qualify cell-based bioassay/potency assays, characterization assays, establish assay acceptance criteria for product characterization, lot release and stability testing applying appropriate statistical tools and comply with regulatory guidelines
Provide testing support for the in-house manufacture of drug substance and drug product

Basic math and software skills (MS Excel, Word, PowerPoint, Graph pad prism, SofmaxPro)
Oversees the reagent inventory, reagent preparation, material ordering for the lab.
Good interpersonal skills, the ability to work individually or as part of a team, and strong problem-solving capabilities. Have strong oral and written communication skills.
Transfer of methods within the in-house QC department.
Experience working in a regulated GMP environment is highly desirable
Process data and present findings at regular team meetings
Write SOPs, technical reports
Document operating procedures for technology transfer and work with CROs/CMOs to implement methods in a GMP environment
In addition, the successful candidate must be comfortable multi-tasking in a fast-paced environment with defined deliverables and deadlines
Compliant with GxP, keep good lab notebook and experiment records

Preferred Experience/Education:

BS, MS, or equivalent degree in biological sciences, biochemistry, chemistry, pharmaceutical sciences, or a related discipline
1-5 years of experience in the biotech/pharmaceutical industry

Knowledge, Skills and Abilities:

In depth knowledge of understanding the mechanism of action (MOA) of biologics and experience in design, and development of mechanism of action (MoA) reflective bioassays using appropriate technologies, such as cell based, ELISA and enzymatic assays experience is required
Experience and knowledge of QC and GMP regulations is essential.
Prior experience in cell culture, cell-based assay is required.
Good understanding of statistical methods/tools for data analysis is strong plus.
Team player, good interpersonal and organizational skills.
Strong written and verbal communication skill
Time management skills and ability to meet deadlines

Supplementary Skills:

Additional techniques: qPCR, ELISA, binding assay, FACS
Experience in GLP or GMP environment
Management of external CROs/CMOs a plus

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Sr. Scientist/Director, Discovery/Preclinical »

Position summary:

We are seeking a talented and dynamic scientist to lead efforts in the discovery and development of novel, oral biological therapeutics to treat severe autoimmune, metabolic and inflammatory diseases. The successful candidate will responsible for the design and implementation of nonclinical programs aimed at identifying and characterizing novel therapeutics and will work in close collaboration with teams throughout the organization, including biology, protein sciences, CMC, regulatory affairs, and clinical development.

Key responsibilities:

Lead cross-functional nonclinical teams to execute development strategies to generate, analyze, and summarize data from studies for inflammatory disease programs.
As a leader in the organization, you will successfully maintain alignment and excellent communications with key stakeholders internally, and ably represent AMT to external collaborators and in public presentations.
Author nonclinical pharmacology reports and nonclinical pharmacology sections of regulatory documents.
Additional activities include managing and identifying key external collaborations that will enhance and/or expedite decisions on projects and/or yield new target opportunities.

Preferred Education/Experience:

Applicants must have a PhD or equivalent degree and at least 8 years of relevant post graduate experience, preferably in industry.
Demonstrated experience in target discovery, translational research, and drug development is strongly preferred. Direct experience in the investigation of pathways or interventional targets related to mucosal immunology and inflammatory bowel disease is optimal.

Knowledge, Skills and Abilities

Excellent communication skills (both written and verbal) and interpersonal skills are required. Must think critically and creatively and be able to work independently, determine appropriate resources for resolution of problems and have strong organizational and planning skills.
The successful candidate must have demonstrated an ability to manage several projects at any given time, to work successfully in a cross-functional and highly collaborative team environment, and to communicate clearly and effectively both verbally and in writing to a variety of audiences.
Previous project leadership in drug discovery preferred
Experience authoring of technical reports, drug discovery documents, and regulatory submissions desired
Demonstrated scientific leadership, mentoring and organizational skills with respect to both managing direct reports as well as external collaborations and/or CROs.

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)