Careers

Applied Molecular Transport (AMT) is a biopharmaceutical company with transformative platform technologies that drive the creation of next generation biological therapeutics, with a particular focus on oral, site-specific targeting to the GI tract, hepatic portal biology, as well as to systemic circulation.

We are a rapidly growing and fast paced company applying foundational scientific principles with the prospect of transforming the biological therapeutics landscape and beneficially impacting the lives of millions of patients who have little to no options.

AMT is looking for top-tier candidates that have a passion and commitment to support the development of the medicines, therapies and 21st century cures that improve and save people’s lives and impact the future of healthcare.

Our team brings industry R&D, business and leadership experience drawn from organizations including Genentech, Amgen, Gilead, AbbVie, Merck, NGM Bio, Sutro Biopharma, BioMarin, Bayer, Lonza, Affymax, Onyx, Kythera, and Celgene.

Available Positions

Research Associate; Upstream Process Development »

Position Summary:

Applied Molecular Transport are looking for an experienced Fermentation Research Associate to develop, optimize and scale-up upstream processes for the production of biopharmaceutical proteins.

Primary Responsibilities

Development and execution of upstream processes to produce novel therapeutic proteins at lab scale.
Set-up and operation of fermentation equipment ranging from 200mL to 30L.
Process monitoring and sampling, including performing routine sample analysis using biological, biochemical, and analytical chemistry assay techniques.
Preparation of media, solutions and buffers.
Participation in daily operation and routine maintenance of process and analytical equipment. Maintaining a clean and organized lab environment. Chemicals and consumables stocking, etc.
Maintenance of lab notebooks and batch records, preparation of SOPs and other technical documentation.

Required Skills

Operation of lab scale fermentation/cell culture equipment, including: fermentors, shake flasks; pH meter, autoclaves, laboratory scales and centrifuges.
Competence in analysis and presentation of experimental results.
Excellent interpersonal and communication (oral and written) skills, documentation, organization, good record keeping, writing reports and SOPs.
Proficiency in cell culture and aseptic technique
Strong technical competency in the scientific principles of fermentation, microbiology and basic chemistry
Attention to detail, safety and good laboratory practice.

Required Experience

A Bachelor’s/Master’sPhD degree or equivalent experience in Chemical Engineering or Microbiology or related field.
At least 2 years of hands-on lab experience working with fermentation equipment.

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

AMT is an equal opportunity employer. In accordance with applicable law, AMT does not discriminate in hiring or otherwise in employment based on race, color, religion, sex, national origin, age, marital or veteran status, disability, sexual orientation, or any other legally protected status. EOE/AA/Vets

Senior Scientist, Protein Science »

Position Summary:

We are seeking a skilled and experienced researcher to join a team focused on the expression and characterization of novel biologic drug candidates that modulate inflammation for the treatment of human diseases.

The successful candidate will be responsible for expressing, purifying, and characterizing recombinant proteins in support of discovery and preclinical development programs. Demonstrable experience with protein expression and purification techniques and protein analytical/characterization methods is required. Strong data analysis skills, the ability to prepare written reports, the ability to present results at research team meetings, and the ability to work productively and collaboratively within a tight-knit team are key assets for this position.

Key Responsibilities:

Strong scientific grounding in protein chemistry and protein structure and function.
Production of recombinant proteins from e. coli cells at up to 1 liter scale.
Experience with refolding of proteins highly desirable.
Laboratory experience in protein purification (e.g. affinity chromatography, size exclusion chromatography, ion exchange chromatography).
Laboratory experience in protein analytical techniques (e.g., SDS-PAGE, HPLC, Western Blot).
Perform data analysis and summarize experimental results, with supervision as appropriate.
Prepare and maintain buffers, reagents and media.
Ensure sufficient laboratory supplies for daily laboratory operations.
Organize, record and maintain experimental data.
Ensure proper operation and perform routine maintenance of laboratory equipment.
Assist other staff to complete laboratory tasks as necessary.
Maintain a clean and safe work environment

Preferred Education/Experience:

B.S. in Biochemical, Chemical, and Biology related discipline with 4-6 years of relevant experience or an MS with 2-4 years, or PhD with 0-2 years. Title and salary will be commensurate with the candidate’s qualifications.

Knowledge, Skills and Abilities:

Must have excellent organization skills and ability to handle multiple tasks.
Highly motivated, willingness to acquire new skills and ability to work with minimal supervision.
Excellent verbal and written communication skills.
Must be proficient in Microsoft Word, Excel, etc.

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Bioassay Analyst, QC »

Position Summary:

Bioassay Development/QC is looking for an analyst with experience in cell-based assay, ELISA or Enzyme/potency/binding plate-based assays. The successful candidate will primarily be responsible to perform laboratory-based activities to design, develop and qualify analytical methods for the characterization, as well as release testing of the Company’s therapeutic drug substance and drug products.

Key Responsibilities:

Develop and qualify cell-based bioassay/potency assays, characterization assays, establish assay acceptance criteria for product characterization, lot release and stability testing applying appropriate statistical tools and comply with regulatory guidelines
Provide testing support for the in-house manufacture of drug substance and drug product

Basic math and software skills (MS Excel, Word, PowerPoint, Graph pad prism, SofmaxPro)
Oversees the reagent inventory, reagent preparation, material ordering for the lab.
Good interpersonal skills, the ability to work individually or as part of a team, and strong problem-solving capabilities. Have strong oral and written communication skills.
Transfer of methods within the in-house QC department.
Experience working in a regulated GMP environment is highly desirable
Process data and present findings at regular team meetings
Write SOPs, technical reports
Document operating procedures for technology transfer and work with CROs/CMOs to implement methods in a GMP environment
In addition, the successful candidate must be comfortable multi-tasking in a fast-paced environment with defined deliverables and deadlines
Compliant with GxP, keep good lab notebook and experiment records

Preferred Experience/Education:

BS, MS, or equivalent degree in biological sciences, biochemistry, chemistry, pharmaceutical sciences, or a related discipline
1-5 years of experience in the biotech/pharmaceutical industry

Knowledge, Skills and Abilities:

In depth knowledge of understanding the mechanism of action (MOA) of biologics and experience in design, and development of mechanism of action (MoA) reflective bioassays using appropriate technologies, such as cell based, ELISA and enzymatic assays experience is required
Experience and knowledge of QC and GMP regulations is essential.
Prior experience in cell culture, cell-based assay is required.
Good understanding of statistical methods/tools for data analysis is strong plus.
Team player, good interpersonal and organizational skills.
Strong written and verbal communication skill
Time management skills and ability to meet deadlines

Supplementary Skills:

Additional techniques: qPCR, ELISA, binding assay, FACS
Experience in GLP or GMP environment
Management of external CROs/CMOs a plus

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Associate/Sr. Associate, Clinical Operations »

Position Summary:

The Clinical Trial Specialist (CTS) will support the Clinical Trial Managers to ensure the success of current and future clinical trials at AMT. The CTS will work with the CTM to assist with the planning and implementation of multiple studies within a clinical development program. The position will also work closely with other cross-functional representatives including Regulatory, Clinical Development, Project Management, and QA to ensure successful completion of all clinical activities/project deliverables within the required time frame. The position will also support oversight of the CRO and other third-party vendors on the assigned study. This individual will report to a Clinical Trial Manager.

Key Responsibilities:

Assist CTMs with activities related to study start-up; investigator site feasibility and selection; essential document review related to investigator site initiation and investigational product release and patient enrollment.
Assist with tracking, reviewing, distribution, and storage of key internal and external documents such as investigator brochures, protocols, interim safety reports, and site/subject material, through the course of the study.
Maintains and disseminates basic study tracking information including, but not limited to: Visit Reports, Regulatory Documents, Site Contact Lists, Team Contact Lists, Vendor metrics, and Enrollment metrics.
Assists CTMs with the oversight of CRO(s) and other study-related, third-party vendors to ensure study requirements are met and study documents are delivered to the Sponsor in a timely manner.
Track study wide clinical supply inventory, vendor supplies at sites and management of study samples.
Ensures electronic trial master files (eTMF) are compliant with relevant regulatory requirements by performing periodic and ad hoc reviews/audits of TMF. This includes the reconciliation of the TMF at study close-out and responding to TMF related inquiries.
Maintains and ensures all documentation is in a state of audit-readiness.
Utilize project management tools (e.g. Outlook, Word, PowerPoint, Timelines, Excel) in order to plan and execute effective meetings with appropriate materials and balance scope and schedule for each trial.
Creates meeting agenda/minute templates and provides drafts of meeting minutes.
Support clinical team efforts to track and contribute to regulatory submissions in the US and globally by coordinating and tracking approvals of clinical documents.
Ensures Good Clinical Practices are followed, ensures protocol deviations are properly recorded, SOPs are maintained and routinely updated, and CRO/site audits are tracked.
Coordinate collection, tracking, and maintenance of updated site regulatory documentation (i.e. FDFs, 1572s, CVs, IRB approvals, etc.).
Develop working knowledge of company standard operating procedures (SOPs) and familiarity with FDA and global regulations related to clinical studies.
Participates in organizing investigator meetings including venue selection, invitations, agenda, and materials distribution.
Communicates effectively with members of the AMT and vendor project teams.
Other tasks or responsibilities as assigned.

Preferred Education/Experience:

A Bachelor’s or Associate’s degree is required. A BA or BS in biological sciences, nursing, or related field is preferred. Prior CTA experience and exposure to clinical trial operations is preferred.

Knowledge, Skills and Abilities:

Knowledge and/or experience of operational aspects of all stages of clinical studies, knowledge of Good Clinical Practice (GCP) and International Conference on Harmonisation (ICH) guidelines.
Familiar with using eTMF, EDC, IRT, CTMS, SharePoint and other vendors systems/portals.
Thrives in a dynamic start‐up environment with busy, high performing colleagues; flexibility to wear multiple hats as needed.
Ability to learn quickly and effectively using newly acquired skills, ability to use time efficiently, multi-task, prioritize, track projects, and follow-through on-time with assigned tasks with exceptional attention to detail.
Excellent organizational and communication skills: Is able to listen and follow instructions; asks questions or clarifications as needed; is transparent and able to communicate clearly and effectively.
Demonstrates accuracy, thoroughness, and thoughtfulness; is able to assess strengths and development areas; Provides quality deliverables and strives to continuously build knowledge and skills.
Strong work ethic; A motivated, positive minded individual who is proactive, flexible and solution oriented to address changing program needs in real time.
Team player who is collaborative, accountable, self-aware; works well in a team environment but can also work independently without significant oversight.
Contributes to building a positive team spirit and company culture; Supports everyone’s efforts to succeed; Shares expertise with others.
Ability to build strong relationships with co-workers of various backgrounds and expertise.

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Research Associate, Pharmaceutical Science »

Position Summary:

Applied Molecular Transport, Inc. has an exciting new opportunity for a Research Associate in the Pharmaceutical Science department. This position will develop novel drug dosage forms for AMT pipeline molecules. The successful candidate will have good understanding of protein chemistry, protein characterization and purification, and strong work responsibility and reliability in a fast-paced drug research environment.

Key Responsibilities:

This is a laboratory-based position.
Perform experiments to support AMT drug discovery and development programs.
Conduct pharmaceutical studies such as drug formulation, dissolution test and bioconjugation.
Characterize drug samples using spectroscopic and chromatography analytical methods such as SEC, RP-HPLC, UV and light scattering.
Analyze, interpret, and accurately record experimental data.
Participate in group meetings, compile and present data for team review.
Document and maintain material inventories and sample logs.

Required Experience/Education:

BS/MS in chemistry, biochemistry, or related discipline.
1-3 years of lab experience in biotech/pharmaceutical industrial setting.

Knowledge, Skills and Abilities:

Experience in wet lab experiments such as chemical reagent handling, chemical and biological sample preparation.
Experience in analytical techniques and instrumentation such as HPLC/UPLC, UV, AKTA, gel electrophoresis. Knowledgeable in protein chemistry, protein purification and bioconjugation.
Attention to detail and can-do attitude. Work independently as well as in team setting.
Strong communication skills and computer skills such as Microsoft Word, Excel, PowerPoint etc.

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Manager/Sr. Manager, Clinical Operations »

Position Summary:

The Clinical Trial Manager/Senior Clinical Trials Manager will be responsible for the operational management and oversight of clinical trials within a clinical development program. The position will work closely with the Medical Monitor and other cross-functional representatives including Clinical Data Management, Biostatistics, Regulatory/QA, Pharmacology and Biology to ensure successful completion of all clinical activities/project deliverables within the required time frame and budget. The position will also provide oversight of the CRO and other third-party vendors on the assigned study. This individual will report into the Head of Clinical Operations.

Key Responsibilities:

Responsible for the planning, implementation and conduct of large, global, complex clinical trials in Phase I-IV; or multiple smaller early-phase studies.
Responsible for oversight and project management of individual studies as well as relevant program related activities with minimal supervision.
Provides leadership within the department and makes recommendations with regards to the operational aspects of executing clinical development deliverables.
Actively provides operational direction and/or general supervision to direct reports
Assist with training and mentoring of internal clinical operations staff.
Establish study milestones and ensure accurate tracking and reporting of study metrics and timelines.
Manage CROs, vendors and consultants that are involved with the clinical trial and program.
Track and report on progress of study including site activation, patient enrollment, monitoring visits
Perform clinical data review of data listings and summary tables, including query generation
Identify, select, and monitor performance of investigational sites for clinical studies; prepare accurate and timely visit reports from all site interaction visits
Develop and maintain good working relationships with investigators and study staff
Ensure studies are carried out according to the study protocol, SOPs, and ICH/GCP regulations and study-specific manuals and procedures
Review key study quality metrics (e.g., eligibility, primary endpoint data, etc.) and determine appropriate action in conjunction with study team (autonomy may vary with experience)
Investigate queries, monitor discrepancies
Manage investigational product (IP) accountability and reconciliation process
Responsible for review or approval of IP release packages
Negotiate and manage the budget and payments for investigative sites
Develop CRA and third-party vendor training on protocols and practices
Participate in program strategy meetings, ad hoc clinical operations’ initiatives and programs as assigned.
Write or contribute to the preparation of clinical protocols, amendments, informed consent forms, study guides, case report forms, and any other clinical research related documents
Perform initial review of CRO and other third-party study vendor invoices to ensure that work is performed in accordance with scope of work
Responsible for the planning, implementation and conduct of large, global, complex clinical trials in Phase I-IV; or multiple smaller early-phase studies.
Responsible for oversight and project management of individual studies as well as relevant program related activities with minimal supervision.
Provides leadership within the department and makes recommendations with regards to the operational aspects of executing clinical development deliverables.
Actively provides operational direction and/or general supervision to direct reports
Assist with training and mentoring of internal clinical operations staff.
Establish study milestones and ensure accurate tracking and reporting of study metrics and timelines.
Manage CROs, vendors and consultants that are involved with the clinical trial and program.
Track and report on progress of study including site activation, patient enrollment, monitoring visits
Perform clinical data review of data listings and summary tables, including query generation
Identify, select, and monitor performance of investigational sites for clinical studies; prepare accurate and timely visit reports from all site interaction visits
Develop and maintain good working relationships with investigators and study staff
Ensure studies are carried out according to the study protocol, SOPs, and ICH/GCP regulations and study-specific manuals and procedures
Review key study quality metrics (e.g., eligibility, primary endpoint data, etc.) and determine appropriate action in conjunction with study team (autonomy may vary with experience)
Investigate queries, monitor discrepancies
Manage investigational product (IP) accountability and reconciliation process
Responsible for review or approval of IP release packages
Negotiate and manage the budget and payments for investigative sites
Develop CRA and third-party vendor training on protocols and practices
Participate in program strategy meetings, ad hoc clinical operations’ initiatives and programs as assigned.
Write or contribute to the preparation of clinical protocols, amendments, informed consent forms, study guides, case report forms, and any other clinical research related documents
Perform initial review of CRO and other third-party study vendor invoices to ensure that work is performed in accordance with scope of work

Preferred Education/Experience:

Bachelor’s degree or higher in a scientific or healthcare discipline preferred with minimum of 5-7 years of progressive experience in clinical research and clinical operations preferably within the biotech, pharmaceutical sector, or CRO environment. Prior experience managing people is desired.

Knowledge, Skills and Abilities:

Extensive experience managing clinical programs, CROs, budgets, and timelines required
Proven experience in the oversight of the operational aspects of all stages of clinical studies
Ability to organize and manage multiple priorities required
Ability to thrive in a fast-paced, entrepreneurial environment with busy, high performing colleagues
Ability to function at a high level in a team setting whether leading the group or acting as an individual contributor
Proactive and positive management approach
Maximum flexibility to adapt to changing program needs in real time
Strong leadership skills and self-awareness
Ability to build strong relationships with co-workers of various backgrounds and expertise

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)

Sr. Scientist/Director, Discovery/Preclinical »

Position summary:

We are seeking a talented and dynamic scientist to lead efforts in the discovery and development of novel, oral biological therapeutics to treat severe autoimmune, metabolic and inflammatory diseases. The successful candidate will responsible for the design and implementation of nonclinical programs aimed at identifying and characterizing novel therapeutics and will work in close collaboration with teams throughout the organization, including biology, protein sciences, CMC, regulatory affairs, and clinical development.

Key responsibilities:

Lead cross-functional nonclinical teams to execute development strategies to generate, analyze, and summarize data from studies for inflammatory disease programs.
As a leader in the organization, you will successfully maintain alignment and excellent communications with key stakeholders internally, and ably represent AMT to external collaborators and in public presentations.
Author nonclinical pharmacology reports and nonclinical pharmacology sections of regulatory documents.
Additional activities include managing and identifying key external collaborations that will enhance and/or expedite decisions on projects and/or yield new target opportunities.

Preferred Education/Experience:

Applicants must have a PhD or equivalent degree and at least 8 years of relevant post graduate experience, preferably in industry.
Demonstrated experience in target discovery, translational research, and drug development is strongly preferred. Direct experience in the investigation of pathways or interventional targets related to mucosal immunology and inflammatory bowel disease is optimal.

Knowledge, Skills and Abilities

Excellent communication skills (both written and verbal) and interpersonal skills are required. Must think critically and creatively and be able to work independently, determine appropriate resources for resolution of problems and have strong organizational and planning skills.
The successful candidate must have demonstrated an ability to manage several projects at any given time, to work successfully in a cross-functional and highly collaborative team environment, and to communicate clearly and effectively both verbally and in writing to a variety of audiences.
Previous project leadership in drug discovery preferred
Experience authoring of technical reports, drug discovery documents, and regulatory submissions desired
Demonstrated scientific leadership, mentoring and organizational skills with respect to both managing direct reports as well as external collaborations and/or CROs.

We invite qualified candidates to submit their CV to: recruiting@appliedmt.com (note: ‘Please put job title in subject heading)